Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an ‘at risk mental state’ (ARMS)

N Katagiri; C Pantelis; T Nemoto; N Tsujino; J Saito; M Hori; T Yamaguchi; T Funatogawa; M Mizuno

Journal article

Longitudinal changes in striatum and sub-threshold positive symptoms in individuals with an ‘at risk mental state’ (ARMS)

N Katagiri, C Pantelis, T Nemoto, N Tsujino, J Saito, M Hori, T Yamaguchi, T Funatogawa, M Mizuno

Psychiatry Research Neuroimaging | ELSEVIER IRELAND LTD | Published : 2019

DOI: 10.1016/j.pscychresns.2019.01.008

Abstract

Recent studies have revealed that several psychotic symptom changes observed in the ‘at risk mental state’ (ARMS) are associated with changes in the striatum. We investigated if structural changes in the striatum are associated with recovery of sub-threshold psychotic symptoms in subjects with an ARMS who did not develop psychosis (ARMS-N). Sixteen healthy controls and 42 subjects with an ARMS participated in this study. Striatal volumes (caudate, putamen, and nucleus accumbens) were analyzed using MRI. The sub-threshold psychotic symptoms of the subjects with an ARMS were measured using the SOPS. Imaging and symptoms were reevaluated after 52 weeks. Significant right putamen volume reductio..

View full abstract

University of Melbourne Researchers

Christos Pantelis Author

Related Projects (2)

RESEARCH FELLOWSHIP - PROF CHRISTOS PANTELIS

I have established and head the Melbourne Neuropsychiatry Centre within the University of Melbourne. My university position is a research ch..

NEUROBIOLOGICAL 'RISK' AND 'RESILIENCE' BIOMARKERS OF SEVERE MENTAL ILLNESS

Mental disorders of childhood (schizotypal disorder, autism spectrum disorders) and adolescence (psychoses, schizophrenia) represent a major..

Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

Naoyuki Katagiri was supported by a JSPS KAKENHI Grant Number 15K19749. Masafumi Mizuno was supported by a Public Grant from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) KAKENHI Grant Number 21591533.Analyzing the data was supported by JSPS KAKENHI Grant Number JP16H06280.Christos Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US; Grant ID: 18722).